Love Lab is set in Fujisaki Girls Academy, which is known for their school body being composed of very prim and proper middle school students. The most prominent one of them is Natsuo Maki, the student council president who is admired by her classmates for her calm and polite demeanor, and her profound beauty. On the other hand, Riko Kurahashi is also admired, but due to her having a very forward and boyish personality.